Common Name(s): Palmitoyl tripeptide-53 amide,palmitoyl tripeptide-53 amide,palmitoyl-anchored tripeptide signal peptide,sc-penetrating anti-aging active
CAS Number: N/a
DESCRIPTION
What It Does: Delivers signal peptide anti-aging activity to the dermis via sc lipid-phase partitioning โ the palmitoyl anchor providing 10-100ร deeper penetration to reach fibroblast collagen synthesis receptors compared to unanchored peptide sequences.
Why It's Used: Palmitoyl anchoring is the most validated approach for signal peptide sc delivery โ the c16 chain provides the optimal length for sc lipid bilayer integration without excessive lipophilicity that would trap the peptide in the sc before reaching dermal fibroblasts.
How It Works: Palmitoyl c16 amide bond: raises peptide logp by ~3 units โ sc lamellar lipid partitioning โ lateral diffusion toward dermis โ skin amidase cleavage โ free active peptide + palmitic acid. released peptide โ tgf-ฮฒ/integrin/collagen receptor binding โ smad/fak โ col1a1/col3a1 upregulation + mmp-1/mmp-3 downregulation.
Typically Found In: Anti-aging serums,collagen products
TECHNICAL DETAILS
Primary Category: Active ingredient โ peptide
Secondary Functions: Collagen synthesis,anti-aging
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 1โ5000 ppm
SOURCING & ETHICS
Vegan Status: Yes
Halal Status: Yes
Source Notes: Synthetically produced via solid-phase peptide synthesis (spps).
SKIN COMPATIBILITY
Irritancy Rating: 1/5 โ very low
Comedogenicity Rating: 0/5 โ non-comedogenic
Sensitivity Concerns: Non-irritating at recommended concentrations.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Excellent safety profile. ewg score: 1.
Works Well With: Retinoids,niacinamide,vitamin c,hyaluronic acid
Avoid Combining With: Strong acids below ph 3.5; oxidising agents
SCIENTIFIC NOTE
Palmitoyl peptide benchmark: palmitoyl-lys-val-lys (pal-kvk, kttks parent) is the reference palmitoyl pentapeptide showing 300% collagen synthesis increase in clinical studies โ all numbered palmitoyl peptides are designed for similar or superior collagen stimulation at equivalent concentrations.
Last Verified: 2026-03-22
Primary Sources: Cosing database,palmitoyl tripeptide-53 amide palmitoyl peptide sc-penetrating review