Common Name(s): Syn-coll,lysyl-valyl-lysine palmitoyl
CAS Number: 623172-56-5
DESCRIPTION
What It Does: Provides direct tgf-beta pathway collagen stimulation as a growth factor-mimetic peptide.
Why It's Used: Growth factor-mimetic peptide — palmitoyl tripeptide-5 activates the same collagen synthesis pathway as tgf-beta growth factor without requiring the growth factor itself, providing collagen stimulation from a stable synthetic peptide.
How It Works: Lys-val-lys tripeptide sequence mimics thrombospondin-1's tgf-beta activating domain. activates latent tgf-beta complex releasing active tgf-beta for fibroblast collagen i synthesis. palmitoyl chain provides skin penetration and depot formation.
Typically Found In: Premium anti-aging serums,wrinkle reduction products
TECHNICAL DETAILS
Primary Category: Active ingredient – tgf-beta mimetic peptide
Secondary Functions: Collagen stimulation,skin firming,anti-aging
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.0001%–0.01%
SOURCING & ETHICS
Vegan Status: Yes – synthetic
Halal Status: Yes
Source Notes: Synthetically produced by solid-phase peptide synthesis (spps). may be palmitoylated for stability.
SKIN COMPATIBILITY
Irritancy Rating: 1/5 – very low
Comedogenicity Rating: 0/5 – non-comedogenic
Sensitivity Concerns: Non-irritating; suitable for all skin types.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Exceptional safety profile. ewg score: 1.
Works Well With: Hyaluronic acid,ceramides,retinol,vitamin c,niacinamide
Avoid Combining With: Avoid mixing with high-concentration ahas at same ph (may hydrolyze peptide bonds)
SCIENTIFIC NOTE
Palmitoyl tripeptide-5's tgf-beta activation via thrombospondin-1 mimicry is clinically elegant: latent tgf-beta is abundant in skin but inactive until cleaved from its latent-associated peptide (lap). thrombospondin-1 normally triggers this activation by disrupting the lap complex. the peptide mimics this activation step, effectively turning on latent tgf-beta already present in skin without requiring exogenous growth factor — activating an endogenous collagen synthesis program.
Last Verified: 2026-03-12
Primary Sources: Cosing database,robinson et al. syn-coll clinical study