Common Name(s): Pal-ghk,palmitoyl gly-his-lys,matrixyl 3000 ha component

CAS Number: 147732-56-7

DESCRIPTION

What It Does: Stimulates collagen, elastin, and glycosaminoglycan synthesis in fibroblasts for wrinkle reduction and skin firming.

Why It's Used: Lipophilic collagen stimulating peptide providing enhanced penetration vs non-palmitoylated forms, used in matrixyl 3000 ha complex.

How It Works: Ghk sequence mimics n-terminal collagen fragment activating collagen and elastin synthesis in fibroblasts. palmitoyl moiety enables passive diffusion through lipid-rich stratum corneum. also promotes glycosaminoglycan (ha) synthesis.

Typically Found In: Anti-aging serums,night creams,anti-wrinkle products

TECHNICAL DETAILS

Primary Category: Active ingredient – matrixyl 3000 component

Secondary Functions: Collagen stimulation,elastin stimulation,ha synthesis

Application Areas:

Typical Concentration Range: 50–500 ppm

SOURCING & ETHICS

Vegan Status: Conditional - supplier confirmation required

Halal Status: Unverified - supplier confirmation required

Source Notes: Synthesized by spps with c-terminal palmitoyl esterification. [audit 2026-07-29 rev2: the record's own source_notes does not assert a non-animal origin, or instructs the reader to verify with the supplier; "yes" asserts knowledge the record does not hold. determination requires shariah-panel sign-off.]

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; suitable for all skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Exceptional safety profile. ewg score: 1.

Works Well With: Hyaluronic acid,ceramides,retinol,vitamin c,niacinamide

Avoid Combining With: Avoid mixing with high-concentration ahas at same ph (may hydrolyze peptide bonds)

SCIENTIFIC NOTE

Ghk tripeptide sequence is a fragment of the n-terminal sequence of collagen alpha-1 chain released during collagen remodeling. it acts as a tissue repair signal to fibroblasts, stimulating collagen types i and iv, elastin, decorin, and glycosaminoglycans.

Last Verified: 2026-03-12

Primary Sources: Cosing database,pickart & margolina ghk review,sederma technical data