Common Name(s): Palmitoyl tetrapeptide-68 amide,amide-stabilised tetrapeptide,anti-aging signal peptide

CAS Number: N/a

DESCRIPTION

What It Does: Stimulates fibroblast collagen i, iii, iv synthesis and inhibits mmp-1 collagen degradation — providing clinically measurable wrinkle reduction and skin firmness.

Why It's Used: Precision pharmacology from spps-synthesised sequence: defined amino acid order targets specific receptor (tgf-beta, egf, or integrin) with quantifiable binding kinetics for mechanism-based efficacy claims.

How It Works: Peptide sequence binds receptor activating map kinase or smad cascades leading to col1a1/col3a1 upregulation and mmp-1/mmp-3 downregulation. amide modification blocks c-terminal carboxypeptidase extending skin half-life 3-5x.

Typically Found In: Anti-aging serums,collagen products

TECHNICAL DETAILS

Primary Category: Active ingredient – signal peptide

Secondary Functions: Collagen stimulation,skin firming,anti-aging

Application Areas:

Typical Concentration Range: 1–5000 ppm

SOURCING & ETHICS

Vegan Status: Yes

Halal Status: Yes

Source Notes: Synthetically produced by solid-phase peptide synthesis (spps). may be palmitoylated for stability.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; suitable for all skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Exceptional safety profile. ewg score: 1.

Works Well With: Hyaluronic acid,ceramides,retinol,vitamin c,niacinamide

Avoid Combining With: Avoid mixing with high-concentration ahas at same ph (may hydrolyze peptide bonds)

SCIENTIFIC NOTE

Spps synthesis provides >98% sequence purity enabling reliable structure-activity relationships — critical because even single amino acid substitution can eliminate receptor binding selectivity.

Last Verified: 2026-03-12

Primary Sources: Cosing database,palmitoyl tetrapeptide-68 amide signal peptide anti-aging review