Common Name(s): Matrixyl,pal-kttks,lys-thr-thr-lys-ser palmitoyl
CAS Number: 214047-00-4
DESCRIPTION
What It Does: Stimulates collagen types i, iii, and iv synthesis in fibroblasts, reducing wrinkles and firming skin.
Why It's Used: Clinically proven signal peptide and the original matrixyl with the strongest evidence base for wrinkle reduction via collagen stimulation. cornerstone of peptide anti-aging formulations.
How It Works: Palmitoyl moiety enables stratum corneum penetration. pal-kttks peptide sequence mimics collagen type i procollagen fragment activating tgf-beta receptor-mediated collagen synthesis in fibroblasts. also stimulates fibronectin and hyaluronan production.
Typically Found In: Anti-aging serums,anti-wrinkle creams,eye treatments,neck creams
TECHNICAL DETAILS
Primary Category: Active ingredient โ matrikine signal peptide
Secondary Functions: Collagen type i stimulation,wrinkle reduction,skin firming
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 1โ1000 ppm (typically 3โ200 ppm)
SOURCING & ETHICS
Vegan Status: Yes โ synthetically produced
Halal Status: Yes
Source Notes: Synthesized by solid-phase peptide synthesis (spps) followed by palmitoylation. commercially supplied in aqueous solution (matrixyl by sederma).
SKIN COMPATIBILITY
Irritancy Rating: 1/5 โ very low
Comedogenicity Rating: 0/5 โ non-comedogenic
Sensitivity Concerns: Non-irritating; suitable for all skin types.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Exceptional safety profile. ewg score: 1.
Works Well With: Hyaluronic acid,ceramides,retinol,vitamin c,niacinamide
Avoid Combining With: Avoid mixing with high-concentration ahas at same ph (may hydrolyze peptide bonds)
SCIENTIFIC NOTE
Lintner & mas-chamberlin (2002) demonstrated pal-kttks upregulates collagen i, iii, and iv as well as fibronectin in fibroblast cultures. a 2.0 ppm clinical trial showed statistically significant wrinkle depth reduction after 4 weeks.
Last Verified: 2026-03-12
Primary Sources: Cosing database,lintner & mas-chamberlin (2002) matrixyl study,gorouhi & maibach peptide review