Common Name(s): Vialox,palmitoyl dipeptide-5
CAS Number: N/a
DESCRIPTION
What It Does: Modulates nicotinic acetylcholine receptors at neuromuscular junction to reduce repetitive muscle contractions causing expression wrinkles.
Why It's Used: Neuromodulator peptide for expression line reduction via nachr antagonism, complementary to snare-inhibiting peptides like argireline.
How It Works: Diaminohydroxybutyrate moiety provides nachr binding affinity. competitive antagonism at nicotinic receptors reduces depolarization frequency and expression muscle contraction intensity.
Typically Found In: Expression line treatments,anti-wrinkle serums
TECHNICAL DETAILS
Primary Category: Active ingredient โ skin restructuring peptide
Secondary Functions: Nachr modulation,expression line reduction
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 100โ1000 ppm
SOURCING & ETHICS
Vegan Status: Conditional - supplier confirmation required
Halal Status: Unverified - supplier confirmation required
Source Notes: Spps synthesis. commercially available as vialox (pentapharm/dsm). [audit 2026-07-29 rev2: the record's own source_notes does not assert a non-animal origin, or instructs the reader to verify with the supplier; "yes" asserts knowledge the record does not hold. determination requires shariah-panel sign-off.]
SKIN COMPATIBILITY
Irritancy Rating: 1/5 โ very low
Comedogenicity Rating: 0/5 โ non-comedogenic
Sensitivity Concerns: Non-irritating; suitable for all skin types.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Exceptional safety profile. ewg score: 1.
Works Well With: Hyaluronic acid,ceramides,retinol,vitamin c,niacinamide
Avoid Combining With: Avoid mixing with high-concentration ahas at same ph (may hydrolyze peptide bonds)
SCIENTIFIC NOTE
Vialox's nachr antagonism mechanism is analogous to syn-ake, providing the same complementarity with snare-inhibiting peptides for synergistic expression line reduction through multiple inhibitory mechanisms.
Last Verified: 2026-03-12
Primary Sources: Cosing database,dsm vialox technical data