Common Name(s): Oridonin,oridonin,rabdosia ent-kauranoid diterpene,anti-inflammatory anti-proliferative active
CAS Number: N/a
DESCRIPTION
What It Does: Provides covalent nf-kb inhibition from the ent-kauranoid's michael acceptor pharmacophore, anti-proliferative activity for anti-keratosis and anti-acne applications, and cox-2 anti-inflammatory activity for skin calming.
Why It's Used: Oridonin's covalent ikk-ฮฒ mechanism provides anti-inflammatory duration exceeding its tissue residence time โ the cys179 adduct persisting for hours after the compound has cleared from skin.
How It Works: Oridonin alpha,beta-unsaturated delta-lactone acts as michael acceptor: c14-c15 exo-cyclic alkene reacts with ikk-ฮฒ cys179 โ covalent adduct โ nf-kb blockade โ cytokine reduction. caspase-3 activation โ apoptosis in hyperproliferative cells (acne comedones, keratosis). cox-2 competitive binding: diterpene hydrophobic active site interaction (ic50 ~5 ฮผm).
Typically Found In: Anti-inflammatory,anti-acne,anti-keratosis
TECHNICAL DETAILS
Primary Category: Active ingredient โ antioxidant
Secondary Functions: Free radical scavenging,anti-aging
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.001%โ0.5%
SOURCING & ETHICS
Vegan Status: Yes
Halal Status: Yes
Source Notes: Plant-derived extract or synthetic.
SKIN COMPATIBILITY
Irritancy Rating: 1/5 โ very low
Comedogenicity Rating: 0/5 โ non-comedogenic
Sensitivity Concerns: Non-irritating; well-tolerated.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Excellent safety profile. ewg score: 1.
Works Well With: Vitamin c,vitamin e,ferulic acid,spf,other antioxidants
Avoid Combining With: No significant incompatibilities
SCIENTIFIC NOTE
Oridonin traditional use: the plant rabdosia rubescens is used in tcm for throat inflammation โ the documented nf-kb anti-inflammatory mechanism provides the mechanistic basis for the traditional anti-inflammatory application.
Last Verified: 2026-03-22
Primary Sources: Cosing database,oridonin ent-kauranoid diterpene nf-kb anti-inflammatory review