Common Name(s): Oligopeptide-161 amide
DESCRIPTION
What It Does: Firms and rejuvenates skin with an amide-stabilized anti-aging peptide.
Why It's Used: Used for skin firming and anti-aging with improved stability from the c-terminal amide modification.
How It Works: C-terminal amide modification improves peptide stability vs proteases; oligopeptide-161 provides anti-aging activity through specific receptor interaction; amide form enhances skin penetration.
Typically Found In: Anti-aging serums,firming products
TECHNICAL DETAILS
Primary Category: Active ingredient โ peptide
Secondary Functions: Anti-aging active,skin conditioning agent
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.001%โ0.1%
SOURCING & ETHICS
Vegan Status: Yes
Halal Status: Yes
Source Notes: Synthetic peptide with c-terminal amide modification.
SKIN COMPATIBILITY
Irritancy Rating: 1/5 โ very low
Comedogenicity Rating: 0/5 โ non-comedogenic
Sensitivity Concerns: Generally well tolerated.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Good safety profile. ewg score: 1.
Works Well With: Other peptides,retinoids
Avoid Combining With: No significant incompatibilities
SCIENTIFIC NOTE
C-terminal amide modification is a common peptide stability-enhancement strategy; it prevents carboxypeptidase degradation of the peptide's c-terminus extending skin residence time.
Last Verified: 2026-03-28
Primary Sources: Cosing database,inci dictionary