Common Name(s): Egf,epidermal growth factor mimic,human oligopeptide-1
CAS Number: 62253-63-8
DESCRIPTION
What It Does: Stimulates keratinocyte proliferation and epidermal renewal for anti-aging and wound healing.
Why It's Used: Used in advanced anti-aging and post-procedure products for egf-like epidermal regeneration signaling.
How It Works: Binds egf receptor (egfr) activating mapk/erk signaling cascade that promotes keratinocyte proliferation, differentiation, and collagen synthesis. also reduces inflammation via pi3k pathway.
Typically Found In: Advanced anti-aging serums,post-procedure recovery,scar treatments
TECHNICAL DETAILS
Primary Category: Active ingredient โ egf-like signal peptide
Secondary Functions: Keratinocyte proliferation,epidermal renewal,wound healing
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.001%โ0.01%
SOURCING & ETHICS
Vegan Status: Conditional - supplier confirmation required
Halal Status: Unverified - supplier confirmation required
Source Notes: Biotechnology-produced small peptide. highly purified for cosmetic use. [audit 2026-07-29 rev2: the record's own source_notes does not assert a non-animal origin, or instructs the reader to verify with the supplier; "yes" asserts knowledge the record does not hold. determination requires shariah-panel sign-off.]
SKIN COMPATIBILITY
Irritancy Rating: 1/5 โ very low
Comedogenicity Rating: 0/5 โ non-comedogenic
Sensitivity Concerns: Non-irritating; well-tolerated.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Excellent safety profile at cosmetic concentrations. ewg score: 1.
Works Well With: Hyaluronic acid,ceramides,peptides,antioxidants
Avoid Combining With: Avoid with harsh ahas that may denature protein structure
SCIENTIFIC NOTE
Full-length egf (53 amino acids) is classified as a drug when applied topically at therapeutic concentrations. oligopeptide-1, as a short egf-mimicking sequence, provides egfr agonism at cosmetic concentrations with regulatory compliance while delivering meaningful epidermal renewal signaling.
Last Verified: 2026-03-12
Primary Sources: Cosing database,bhora et al. egf wound healing review,gorouhi & maibach peptide review