Common Name(s): Octapeptide-28,octapeptide-28,octapeptide-28,anti-aging signal peptide

CAS Number: N/a

DESCRIPTION

What It Does: Stimulates fibroblast collagen i, iii, iv synthesis and inhibits mmp-1 matrix metalloproteinase collagen degradation — providing clinically measurable wrinkle reduction and skin firmness at 1–5000 ppm concentrations.

Why It's Used: Octapeptide sequences provide optimal receptor-binding geometry — long enough for full receptor docking with appropriate conformational flexibility while short enough for formulation stability and sc penetration.

How It Works: Peptide receptor binding → map kinase or smad cascade → col1a1/col3a1 upregulation + mmp-1/mmp-3 downregulation. spps synthesis provides >98% sequence purity for reproducible pharmacological response.

Typically Found In: Anti-aging serums,collagen products

TECHNICAL DETAILS

Primary Category: Active ingredient – peptide

Secondary Functions: Collagen synthesis,anti-aging

Application Areas:

Typical Concentration Range: 1–5000 ppm

SOURCING & ETHICS

Vegan Status: Yes

Halal Status: Yes

Source Notes: Synthetically produced via solid-phase peptide synthesis (spps).

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating at recommended concentrations.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Retinoids,niacinamide,vitamin c,hyaluronic acid

Avoid Combining With: Strong acids below ph 3.5; oxidising agents

SCIENTIFIC NOTE

Inci registry numbering: each numbered octapeptide designates a unique amino acid sequence — different numbers target different receptor subtypes (tgf-β r1/2, egf-r, integrin α2β1, α5β1, αvβ3) for complementary anti-aging mechanisms.

Last Verified: 2026-03-22

Primary Sources: Cosing database,octapeptide-28 signal peptide anti-aging review