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Common Name(s): Oat beta-glucan,1,3/1,4-beta-glucan,glucan extract

CAS Number: 9041-22-9

DESCRIPTION

What It Does: Stimulates skin immune defense while providing deep hydration and wound healing through glucan receptor signaling.

Why It's Used: Multi-function polysaccharide combining deep hydration with unique immunomodulatory wound healing activity unavailable from standard humectants.

How It Works: Binds dectin-1 and tlr2 receptors on macrophages and dendritic cells stimulating immune activation and wound healing cytokine release. viscous polysaccharide forms hydrating film retaining 100ร— its weight in water. direct antioxidant via hydroxyl groups.

Typically Found In: Wound healing products,immunomodulatory serums,deep hydration products,anti-aging

TECHNICAL DETAILS

Primary Category: Active ingredient โ€“ soothing / anti-inflammatory

Secondary Functions: Dectin-1 receptor activation,wound healing,deep hydration

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%โ€“5%

SOURCING & ETHICS

Vegan Status: Yes โ€“ from oat bran or yeast (saccharomyces cerevisiae)

Halal Status: Yes

Source Notes: Plant-derived extract or synthetic.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 โ€“ very low

Comedogenicity Rating: 0/5 โ€“ non-comedogenic

Sensitivity Concerns: Non-irritating; ideal for reactive and sensitive skin.

Safe for Sensitive Skin: Yes โ€“ particularly recommended for sensitive skin

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Ceramides,panthenol,allantoin,hyaluronic acid,centella asiatica

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Beta-glucan's receptor-mediated wound healing through dectin-1 activation is fundamentally different from simple polysaccharide humectant effects โ€“ it actively recruits and activates immune cells to the wound site, accelerating the immune phase of wound healing that determines subsequent repair quality and scar outcome.

Last Verified: 2026-03-12

Primary Sources: Cosing database,schepetkin & quinn beta-glucan immunostimulation review