Back to Ingredient Dictionary

Nordihydroguaiaretic Acid

Description

Nordihydroguaiaretic Acid (NDGA) is a potent antioxidant compound derived from the creosote bush, Larrea tridentata. This polyphenolic substance has garnered significant attention in skincare formulations due to its multifaceted benefits. NDGA exhibits strong free radical scavenging properties, effectively neutralizing reactive oxygen species that contribute to premature skin aging and cellular damage. Its anti-inflammatory capabilities make it particularly useful in addressing various skin concerns, including redness and irritation associated with sensitive or compromised skin barriers.

Research has demonstrated NDGA's potential in inhibiting matrix metalloproteinases (MMPs), enzymes responsible for breaking down collagen and elastin in the skin. This inhibition may contribute to improved skin elasticity and reduced appearance of fine lines and wrinkles. Additionally, NDGA has shown promise in regulating melanin production, potentially aiding in the management of hyperpigmentation and uneven skin tone. Its ability to modulate lipid peroxidation further enhances its protective effects against environmental stressors.

When incorporated into skincare formulations, NDGA is typically used at concentrations between 0.1% to 1%. However, due to its potency, it's crucial to carefully consider its concentration and potential interactions with other active ingredients to ensure optimal efficacy and skin tolerability.