Back to Ingredient Dictionary

NONAPEPTIDE-38

Description

Nonapeptide-38 is an innovative synthetic peptide designed for advanced skincare formulations. This compound consists of a specific sequence of nine amino acids, strategically engineered to target melanin production in the skin. Its primary function is to inhibit tyrosinase, a key enzyme in melanogenesis, effectively reducing hyperpigmentation and promoting a more even skin tone.

Clinical studies have shown that Nonapeptide-38 can significantly decrease melanin synthesis without cytotoxic effects on melanocytes. This makes it a safer alternative to traditional skin-lightening agents like hydroquinone. The peptide works by interfering with the melanocyte-stimulating hormone (α-MSH) signaling pathway, which is responsible for triggering melanin production.

In skincare formulations, Nonapeptide-38 is typically used at concentrations between 0.005% to 0.01%. It is water-soluble and stable in a pH range of 4.0 to 7.0, making it compatible with various cosmetic bases. This ingredient is particularly beneficial in products targeting age spots, melasma, and post-inflammatory hyperpigmentation. For optimal results, it is often combined with other brightening agents such as vitamin C or niacinamide in comprehensive skin-lightening regimens.