Common Name(s): Nonanoyl tryptamine,nonanoyl tryptamine,n-acyl amino acid conjugate,dual-function bioactive

CAS Number: N/a

DESCRIPTION

What It Does: Provides dual-function activity from the acyl chain's sc penetration and the amino acid/amine component's specific receptor or metabolic pharmacology.

Why It's Used: N-acyl conjugation is a universal bioavailability enhancement strategy — the fatty acid chain improves sc penetration while delivering the amino acid active to deeper skin layers.

How It Works: Acyl chain → logp increase → sc lipid-phase penetration → deeper delivery. amino acid/amine component → specific receptor binding or metabolic cofactor activity after enzymatic deconjugation.

Typically Found In: Anti-aging,skin conditioning

TECHNICAL DETAILS

Primary Category: Active ingredient – antioxidant

Secondary Functions: Free radical scavenging,anti-aging

Application Areas:

Typical Concentration Range: 0.01%–2%

SOURCING & ETHICS

Vegan Status: Yes

Halal Status: Yes

Source Notes: Plant-derived extract or synthetic.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; well-tolerated.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Vitamin c,vitamin e,ferulic acid,spf,other antioxidants

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Amide bond hydrolysis: n-acyl amides are slowly hydrolysed by skin amidases — slower release than ester bonds provides sustained active delivery over hours.

Last Verified: 2026-03-22

Primary Sources: Cosing database,nonanoyl tryptamine n-acyl conjugate bioactive review