Common Name(s): Nicotinoyl dipeptide-24,nicotinoyl dipeptide-24,nicotinoyl signal peptide,niacinamide-conjugated anti-aging active
CAS Number: N/a
DESCRIPTION
What It Does: Provides combined anti-aging collagen synthesis from the peptide receptor pharmacology and brightening from the nicotinoyl melanin transfer inhibition โ dual mechanism from one molecular scaffold.
Why It's Used: Nicotinoyl-peptide conjugation combines the brightening and anti-aging activities of niacinamide with the receptor-targeted collagen stimulation of signal peptides โ each component independently active but synergistic in combination.
How It Works: Nicotinoyl ring: niacinamide activity โ melanin transfer synapse par-2 inhibition โ brightening. peptide sequence โ tgf-ฮฒ/integrin receptor โ smad2/3 โ col1a1 upregulation. the conjugate delivers both pharmacophores in one molecule with sc penetration from the combined molecular architecture.
Typically Found In: Brightening,anti-aging serums
TECHNICAL DETAILS
Primary Category: Active ingredient โ peptide
Secondary Functions: Collagen synthesis,anti-aging
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 1โ5000 ppm
SOURCING & ETHICS
Vegan Status: Yes
Halal Status: Yes
Source Notes: Synthetically produced via solid-phase peptide synthesis (spps).
SKIN COMPATIBILITY
Irritancy Rating: 1/5 โ very low
Comedogenicity Rating: 0/5 โ non-comedogenic
Sensitivity Concerns: Non-irritating at recommended concentrations.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Excellent safety profile. ewg score: 1.
Works Well With: Retinoids,niacinamide,vitamin c,hyaluronic acid
Avoid Combining With: Strong acids below ph 3.5; oxidising agents
SCIENTIFIC NOTE
Nicotinoyl conjugate ph stability: niacinamide is stable at ph 4-8 enabling broad formulation compatibility; peptide sequence stability may require ph 5-7 and antioxidant protection for thiol-containing residues.
Last Verified: 2026-03-22
Primary Sources: Cosing database,nicotinoyl dipeptide-24 nicotinoyl peptide anti-aging brightening review