Common Name(s): Nicotiana benthamiana sh-polipedtide-45,nicotiana benthamiana sh-polipedtide-45,plant-expressed recombinant peptide,nicotiana viral expression system
CAS Number: N/a
DESCRIPTION
What It Does: Provides signal peptide anti-aging activity (collagen synthesis stimulation, mmp inhibition) identical to spps-synthesised peptides but produced through plant-based recombinant expression โ enabling the same receptor pharmacology with sustainable plant-based production credentials.
Why It's Used: Nicotiana benthamiana viral expression provides pharmaceutical-grade peptide production in plant cells โ the tobacco mosaic virus or potato virus x-based vectors infecting the entire plant within 4-7 days for rapid scalable production impossible with chemical synthesis.
How It Works: Tobacco viral expression: agrobacterium vacuum infiltration of n. benthamiana โ peaq-ht or tmv-based vector system โ ribosome translation โ recombinant peptide accumulation in apoplast or cytoplasm โ extraction/purification. identical amino acid sequence to spps-synthesised counterparts providing equivalent receptor pharmacology.
Typically Found In: Anti-aging serums,sustainable biotech
TECHNICAL DETAILS
Primary Category: Active ingredient โ peptide
Secondary Functions: Collagen synthesis,anti-aging
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 1โ5000 ppm
SOURCING & ETHICS
Vegan Status: Yes
Halal Status: Yes
Source Notes: Synthetically produced via solid-phase peptide synthesis (spps).
SKIN COMPATIBILITY
Irritancy Rating: 1/5 โ very low
Comedogenicity Rating: 0/5 โ non-comedogenic
Sensitivity Concerns: Non-irritating at recommended concentrations.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Excellent safety profile. ewg score: 1.
Works Well With: Retinoids,niacinamide,vitamin c,hyaluronic acid
Avoid Combining With: Strong acids below ph 3.5; oxidising agents
SCIENTIFIC NOTE
Plant expression regulatory note: plant-derived recombinant proteins may require novel ingredient assessment in eu (sccs opinion) โ the plant-expressed status and recombinant protein characterisation documentation should accompany the ingredient in regulatory submission.
Last Verified: 2026-03-22
Primary Sources: Cosing database,nicotiana benthamiana sh-polipedtid nicotiana plant-expressed recombinant peptide review