Common Name(s): Flavonoid antioxidant,plant polyphenol complex,anti-inflammatory brightening

CAS Number: N/a

DESCRIPTION

What It Does: Scavenges uv and pollution-derived free radicals via phenol h• donation, inhibits inflammatory nf-kb, cox-2, and 5-lox enzymes, and provides tyrosinase inhibition for hyperpigmentation treatment.

Why It's Used: Flavonoids provide the broadest multi-target anti-inflammatory coverage of any plant compound class — simultaneous cox, lox, and nf-kb inhibition from one ingredient addresses prostaglandin, leukotriene, and cytokine inflammatory pathways simultaneously.

How It Works: Multiple catechol and hydroxyl groups provide radical scavenging (dpph ic₅₀ 2–50 μm for most flavonoids); the catechol b-ring chelates fe²⁺ and cu²⁺ preventing fenton reaction; nf-kb inhibition occurs through ikb kinase modification; tyrosinase inhibition from catechol coordination to the active site cu²⁺.

Typically Found In: Anti-aging,anti-inflammatory,brightening botanicals

TECHNICAL DETAILS

Primary Category: Active ingredient – antioxidant

Secondary Functions: Free radical scavenging,anti-aging

Application Areas:

Typical Concentration Range: 0.05%–2%

SOURCING & ETHICS

Vegan Status: Conditional - supplier confirmation required

Halal Status: Unverified - supplier confirmation required

Source Notes: Plant-derived extract or synthetic. [audit 2026-07-29 rev2: status downgraded on audit. determination requires shariah-panel sign-off.]

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; well-tolerated.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Vitamin c,vitamin e,ferulic acid,spf,other antioxidants

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Quercetin's multi-target activity spectrum spans antioxidant (dpph ic₅₀ 4 μm), 12-lox inhibition (ic₅₀ 0.8 μm), nf-kb inhibition (ic₅₀ 15 μm), and tyrosinase inhibition (ic₅₀ 25 μm) — the breadth of multi-pathway coverage explaining why flavonoids are the most studied natural anti-inflammatory compound class.

Last Verified: 2026-03-12

Primary Sources: Cosing database,flavonoid multi-target antioxidant anti-inflammatory review