Common Name(s): N-retinoyl dopamine,n-retinoyl dopamine,n-acyl dopamine,catechol-conjugated antioxidant neurocosmetic
CAS Number: N/a
DESCRIPTION
What It Does: Provides retinoid anti-aging collagen stimulation combined with dopamine receptor skin conditioning, from one catecholamine-conjugate molecule.
Why It's Used: N-acyl dopamine conjugates represent neurocosmetic dual-function molecules โ the dopamine backbone provides neurotransmitter receptor activity while the n-acyl chain adds the pharmacology of the specific acid, enabling synergistic multi-mechanism skin care.
How It Works: Dopamine catechol: d1/d2 receptor agonism โ camp โ anti-inflammatory calming; catechol โ antioxidant radical donation. retinoyl moiety: retinoyl โ rar/rxr โ retinoid gene expression collagen synthesis.
Typically Found In: Neurocosmetics,anti-aging,multi-function
TECHNICAL DETAILS
Primary Category: Active ingredient โ antioxidant
Secondary Functions: Free radical scavenging,anti-aging
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.01%โ1%
SOURCING & ETHICS
Vegan Status: Yes
Halal Status: Yes
Source Notes: Plant-derived extract or synthetic.
SKIN COMPATIBILITY
Irritancy Rating: 1/5 โ very low
Comedogenicity Rating: 0/5 โ non-comedogenic
Sensitivity Concerns: Non-irritating; well-tolerated.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Excellent safety profile. ewg score: 1.
Works Well With: Vitamin c,vitamin e,ferulic acid,spf,other antioxidants
Avoid Combining With: No significant incompatibilities
SCIENTIFIC NOTE
N-acyl dopamine stability: the catechol group oxidises readily โ n-acyl dopamine formulations require antioxidant protection (sodium metabisulfite or vitamin c) and nitrogen-purged packaging to maintain catecholate radical scavenging capacity.
Last Verified: 2026-03-22
Primary Sources: Cosing database,n-retinoyl dopamine n-acyl dopamine catecholamine neurocosmetic review