Common Name(s): N-prolyl palmitoyl tripeptide-56 acetate,n-prolyl palmitoyl tripeptide-56 acetate,n-acyl amino acid conjugate,dual-function bioactive
CAS Number: N/a
DESCRIPTION
What It Does: Provides dual-function activity from the acyl chain's sc penetration and the amino acid/amine component's specific receptor or metabolic pharmacology.
Why It's Used: N-acyl conjugation is a universal bioavailability enhancement strategy โ the fatty acid chain improves sc penetration while delivering the amino acid active to deeper skin layers.
How It Works: Acyl chain โ logp increase โ sc lipid-phase penetration โ deeper delivery. amino acid/amine component โ specific receptor binding or metabolic cofactor activity after enzymatic deconjugation.
Typically Found In: Anti-aging,skin conditioning
TECHNICAL DETAILS
Primary Category: Active ingredient โ antioxidant
Secondary Functions: Free radical scavenging,anti-aging
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.01%โ2%
SOURCING & ETHICS
Vegan Status: Yes
Halal Status: Yes
Source Notes: Plant-derived extract or synthetic.
SKIN COMPATIBILITY
Irritancy Rating: 1/5 โ very low
Comedogenicity Rating: 0/5 โ non-comedogenic
Sensitivity Concerns: Non-irritating; well-tolerated.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Excellent safety profile. ewg score: 1.
Works Well With: Vitamin c,vitamin e,ferulic acid,spf,other antioxidants
Avoid Combining With: No significant incompatibilities
SCIENTIFIC NOTE
Amide bond hydrolysis: n-acyl amides are slowly hydrolysed by skin amidases โ slower release than ester bonds provides sustained active delivery over hours.
Last Verified: 2026-03-22
Primary Sources: Cosing database,n-prolyl palmitoyl tripeptide-56 acetate n-acyl conjugate bioactive review