Common Name(s): Minoxidil hyaluronamide,minoxidil hyaluronamide,ha-conjugated hair growth active,scalp-targeted minoxidil delivery

CAS Number: N/a

DESCRIPTION

What It Does: Delivers minoxidil to scalp follicles through ha-mediated cd44 receptor-targeting for sustained katp channel activation in vascular smooth muscle, providing vasodilation and improved follicular microcirculation for hair growth stimulation with reduced systemic absorption risk.

Why It's Used: Ha conjugation provides topical minoxidil delivery advantages over free minoxidil — the ha backbone's cd44 receptor affinity concentrating the active at the follicular dermal papilla target while reducing transdermal systemic absorption.

How It Works: Minoxidil activates katp (atp-sensitive potassium) channels in vascular smooth muscle → k+ efflux → membrane hyperpolarisation → ca2+ channel closure → smooth muscle relaxation → arteriole vasodilation → improved follicular perfusion → prolonged anagen (growth) phase. ha backbone binds scalp cd44 receptors providing sustained follicular delivery with the ha carrier's dermal penetration properties.

Typically Found In: Hair growth serums,alopecia treatment

TECHNICAL DETAILS

Primary Category: Active ingredient – cosmetic active

Secondary Functions: Skin conditioning

Application Areas:

Typical Concentration Range: 0.01%–5%

SOURCING & ETHICS

Vegan Status: Conditional - supplier confirmation required

Halal Status: Unverified - supplier confirmation required

Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier. [audit 2026-07-29 rev2: the record's own source_notes does not assert a non-animal origin, or instructs the reader to verify with the supplier; "yes" asserts knowledge the record does not hold. determination requires shariah-panel sign-off.]

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Well-tolerated by most skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Good safety profile at recommended concentrations. ewg score: 1–2.

Works Well With: Standard skincare actives

Avoid Combining With: No known significant incompatibilities

SCIENTIFIC NOTE

Minoxidil regulatory classification varies by market — in many countries minoxidil is a pharmaceutical active requiring drug regulatory approval even in cosmetic hair products. ha conjugation may alter the pharmacological classification — formulators must verify each target market's regulatory status for this conjugate.

Last Verified: 2026-03-22

Primary Sources: Cosing database,fda minoxidil,minoxidil hyaluronamide scalp delivery review