Common Name(s): Methylthioadenosine,methylthioadenosine (mta),polyamine pathway regulator,anti-inflammatory wound healing purine
CAS Number: N/a
DESCRIPTION
What It Does: Activates adenosine a2a receptors for anti-inflammatory camp-mediated tnf-ฮฑ suppression, modulates the polyamine pathway for wound healing and cell proliferation support, and provides the wound-healing growth signalling of the polyamine biosynthesis intermediate.
Why It's Used: Mta is a metabolic signal molecule at the intersection of polyamine biosynthesis and methylation โ naturally produced wherever cells are actively making polyamines (spermidine, spermine), providing the same anti-inflammatory and wound-healing signals as cellular energy status.
How It Works: Mta: adenosine receptor (a2a) agonism โ gs โ camp โ pka โ creb โ anti-inflammatory gene expression (il-10, tgf-ฮฒ), tnf-ฮฑ suppression. simultaneously, mta inhibits methylthioadenosine phosphorylase (mtap) in cancer cells (selectively expressed) providing anti-proliferative activity. polyamine pathway: mta โ methionine recycling โ sam regeneration โ methylation reactions.
Typically Found In: Anti-inflammatory,wound healing,premium biology
TECHNICAL DETAILS
Primary Category: Active ingredient โ antioxidant
Secondary Functions: Free radical scavenging,anti-aging
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.001%โ0.5%
SOURCING & ETHICS
Vegan Status: Yes
Halal Status: Yes
Source Notes: Plant-derived extract or synthetic.
SKIN COMPATIBILITY
Irritancy Rating: 1/5 โ very low
Comedogenicity Rating: 0/5 โ non-comedogenic
Sensitivity Concerns: Non-irritating; well-tolerated.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Excellent safety profile. ewg score: 1.
Works Well With: Vitamin c,vitamin e,ferulic acid,spf,other antioxidants
Avoid Combining With: No significant incompatibilities
SCIENTIFIC NOTE
Mta skin wound healing: topical mta at 0.1-1 mm accelerates keratinocyte migration in scratch assay models through a2a receptor-mediated camp/pka pathway โ providing direct evidence for skin wound healing activity beyond the anti-inflammatory mechanism.
Last Verified: 2026-03-22
Primary Sources: Cosing database,methylthioadenosine mta a2a anti-inflammatory wound healing review