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Common Name(s): Methoxyphenyl menthane carboxamide,methoxyphenyl menthane carboxamide,cooling agent,trpm8 activator non-menthol cooling

CAS Number: N/a

DESCRIPTION

What It Does: Provides intense trpm8-mediated cooling sensation at concentrations 10-100ร— lower than menthol โ€” the carboxamide pharmacophore providing high receptor affinity with minimal peppermint fragrance.

Why It's Used: Synthetic cooling agents separate cooling function from menthol fragrance โ€” enabling cooling product positioning in applications where maximum cooling with minimal peppermint scent is desired.

How It Works: Cyclohexane/menthane carboxamide scaffold binds trpm8 hydrophobic pocket (s1-s4 transmembrane domain): carboxamide c=o h-bonds tyr745; alkyl chain occupies lipophilic groove. higher binding affinity than menthol (ec50 0.1-1 ฮผm vs menthol 10 ฮผm) โ€” equivalent cooling at 10-100ร— lower concentration.

Typically Found In: Cooling cosmetics,oral care,after-sun

TECHNICAL DETAILS

Primary Category: Active ingredient โ€“ cosmetic active

Secondary Functions: Skin conditioning

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.001%โ€“0.1%

SOURCING & ETHICS

Vegan Status: Conditional - supplier confirmation required

Halal Status: Unverified - supplier confirmation required

Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier. [audit 2026-07-29 rev2: the record's own source_notes does not assert a non-animal origin, or instructs the reader to verify with the supplier; "yes" asserts knowledge the record does not hold. determination requires shariah-panel sign-off.]

SKIN COMPATIBILITY

Irritancy Rating: 1/5 โ€“ very low

Comedogenicity Rating: 0/5 โ€“ non-comedogenic

Sensitivity Concerns: Well-tolerated by most skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Good safety profile at recommended concentrations. ewg score: 1โ€“2.

Works Well With: Standard skincare actives

Avoid Combining With: No known significant incompatibilities

SCIENTIFIC NOTE

Cooling duration: carboxamide trpm8 agonists have longer receptor residence time than menthol ether โ€” the stronger binding providing 2-3ร— longer cooling sensation duration from single application.

Last Verified: 2026-03-22

Primary Sources: Cosing database,methoxyphenyl menthane carboxamide synthetic cooling trpm8 review