Common Name(s): Methotrexoyl oligopeptide-59,methotrexoyl oligopeptide-59,signal peptide or amino acid conjugate,anti-aging bioactive
CAS Number: N/a
DESCRIPTION
What It Does: Provides receptor-mediated anti-aging activity, enzymatic cofactor support, or amino acid metabolic conditioning at recommended cosmetic concentrations.
Why It's Used: Precision amino acid and peptide actives provide mechanism-based anti-aging efficacy from defined molecular structure enabling quantifiable pharmacological responses.
How It Works: Amino acid/peptide interaction with skin: receptor binding โ kinase cascade โ gene expression; enzyme cofactor โ metabolic pathway support; osmolyte โ cellular stress protection.
Typically Found In: Anti-aging serums,collagen products
TECHNICAL DETAILS
Primary Category: Active ingredient โ peptide
Secondary Functions: Collagen synthesis,anti-aging
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 1โ5000 ppm
SOURCING & ETHICS
Vegan Status: Yes
Halal Status: Yes
Source Notes: Synthetically produced via solid-phase peptide synthesis (spps).
SKIN COMPATIBILITY
Irritancy Rating: 1/5 โ very low
Comedogenicity Rating: 0/5 โ non-comedogenic
Sensitivity Concerns: Non-irritating at recommended concentrations.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Excellent safety profile. ewg score: 1.
Works Well With: Retinoids,niacinamide,vitamin c,hyaluronic acid
Avoid Combining With: Strong acids below ph 3.5; oxidising agents
SCIENTIFIC NOTE
Stability considerations: maintain ph 5-7; avoid oxidising conditions affecting thiol and tryptophan residues; encapsulation where applicable for hydrophobic sequences.
Last Verified: 2026-03-22
Primary Sources: Cosing database,methotrexoyl oligopeptide-59 peptide amino acid review