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HYDROXYPROPYL METHYLCELLULOSE ACETATE/SUCCINATE

Description

Hydroxypropyl methylcellulose acetate/succinate (HPMCAS) is a versatile, semi-synthetic polymer derived from cellulose. This multifunctional ingredient serves as an effective film-former, binder, and stabilizer in various skincare and pharmaceutical formulations. HPMCAS exhibits excellent solubility-enhancing properties, making it particularly valuable for improving the bioavailability of poorly water-soluble active ingredients.

In skincare applications, HPMCAS acts as a protective barrier, forming a thin, flexible film on the skin's surface. This film helps to lock in moisture, reduce transepidermal water loss, and shield the skin from environmental stressors. The polymer's unique chemical structure allows for controlled release of active ingredients, ensuring sustained delivery over time.

HPMCAS demonstrates remarkable stability across a wide pH range and is resistant to enzymatic degradation. Its low hygroscopicity contributes to improved product shelf-life and stability. The ingredient is generally recognized as safe (GRAS) by the FDA and is well-tolerated by most skin types. Formulators often incorporate HPMCAS in serums, moisturizers, and topical medications to enhance product performance and improve the overall efficacy of active ingredients.