Back to Ingredient Dictionary

HYDROXYETHYLPIPERAZINE ETHANE SULFONIC ACID

Description

Hydroxyethylpiperazine Ethane Sulfonic Acid (HEPES) is a zwitterionic organic chemical buffering agent widely used in cell culture and biochemical applications. In skincare formulations, HEPES has gained attention for its potential to maintain optimal pH levels and enhance product stability. This compound has a pKa of 7.5 at 25��C, making it particularly effective in maintaining physiological pH ranges similar to human skin.

HEPES exhibits excellent buffering capacity in the 6.8-8.2 pH range, crucial for preserving the efficacy of active ingredients in skincare products. Its chemical structure allows it to resist changes in pH caused by temperature fluctuations or the addition of other ingredients. This stability contributes to improved shelf life and consistent performance of formulations.

In skincare, HEPES may help to create an environment conducive to the optimal function of other ingredients, potentially enhancing their efficacy. It has been explored for its ability to support skin barrier function and maintain skin homeostasis. While research is ongoing, preliminary studies suggest HEPES may have antioxidant properties and could contribute to protecting skin cells from oxidative stress.