Common Name(s): Hydrolyzed oyster extract,hydrolyzed oyster extract,peptide hydrolysate,bioactive peptide complex

CAS Number: N/a

DESCRIPTION

What It Does: Provides bioactive collagen synthesis stimulation from gly-pro-hyp sequence receptor binding, hygroscopic amino acid humectancy from the peptide mixture, and skin conditioning from substantive peptide-keratin interaction on the sc surface.

Why It's Used: Protease hydrolysis generates the bioactive peptide fragments that intact proteins cannot deliver — the gly-pro-hyp tripeptide from collagen hydrolysis directly stimulates fibroblast procollagen synthesis through gfpger receptor binding, unavailable from native collagen.

How It Works: Protease hydrolysis (proteinase k, bromelain, papain, subtilisin) cleaves amide bonds → peptide mixture. optimal fragment size for receptor binding: 500-2000 da (3-15 residues). gly-pro-hyp sequences (abundant in collagen) bind discoidin domain receptor (ddr) and α2β1 integrin → col1a1 upregulation. sc substantivity: cationic peptide fragments (+charge at ph 5.5) adsorb to anionic sc keratin.

Typically Found In: Anti-aging,skin conditioning,premium proteins

TECHNICAL DETAILS

Primary Category: Active ingredient – antioxidant

Secondary Functions: Free radical scavenging,anti-aging

Application Areas:

Typical Concentration Range: 0.5%–10%

SOURCING & ETHICS

Vegan Status: No - animal-derived

Halal Status: Contested - marine invertebrate; madhhab-dependent (shafi'i and maliki permit broadly, hanafi restricts to fish), refer to certifier stance

Source Notes: Plant-derived extract or synthetic. [audit 2026-07-29 rev2: marine invertebrate; permissibility splits by school of law. determination requires shariah-panel sign-off.]

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; well-tolerated.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Vitamin c,vitamin e,ferulic acid,spf,other antioxidants

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Hydrolysate mw distribution is the key quality parameter — peptide mw distribution by sec-mals determines the relative proportions of large (film-forming) to small (receptor-active) peptide fractions. suppliers should provide mw profile for formulation-specific selection.

Last Verified: 2026-03-22

Primary Sources: Cosing database,hydrolyzed oyster extract protein hydrolysate bioactive peptide review