Common Name(s): Hydrolyzed milt extract,hydrolyzed milt extract,peptide hydrolysate,bioactive peptide complex
CAS Number: N/a
DESCRIPTION
What It Does: Provides bioactive collagen synthesis stimulation from gly-pro-hyp sequence receptor binding, hygroscopic amino acid humectancy from the peptide mixture, and skin conditioning from substantive peptide-keratin interaction on the sc surface.
Why It's Used: Protease hydrolysis generates the bioactive peptide fragments that intact proteins cannot deliver — the gly-pro-hyp tripeptide from collagen hydrolysis directly stimulates fibroblast procollagen synthesis through gfpger receptor binding, unavailable from native collagen.
How It Works: Protease hydrolysis (proteinase k, bromelain, papain, subtilisin) cleaves amide bonds → peptide mixture. optimal fragment size for receptor binding: 500-2000 da (3-15 residues). gly-pro-hyp sequences (abundant in collagen) bind discoidin domain receptor (ddr) and α2β1 integrin → col1a1 upregulation. sc substantivity: cationic peptide fragments (+charge at ph 5.5) adsorb to anionic sc keratin.
Typically Found In: Anti-aging,skin conditioning,premium proteins
TECHNICAL DETAILS
Primary Category: Active ingredient – antioxidant
Secondary Functions: Free radical scavenging,anti-aging
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.5%–10%
SOURCING & ETHICS
Vegan Status: Conditional - supplier confirmation required
Halal Status: Conditional - basis not stated in source record; supplier origin confirmation required to determine what evidence applies
Source Notes: Plant-derived extract or synthetic. [audit 2026-07-29 rev2: status downgraded on audit. determination requires shariah-panel sign-off.]
SKIN COMPATIBILITY
Irritancy Rating: 1/5 – very low
Comedogenicity Rating: 0/5 – non-comedogenic
Sensitivity Concerns: Non-irritating; well-tolerated.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Excellent safety profile. ewg score: 1.
Works Well With: Vitamin c,vitamin e,ferulic acid,spf,other antioxidants
Avoid Combining With: No significant incompatibilities
SCIENTIFIC NOTE
Hydrolysate mw distribution is the key quality parameter — peptide mw distribution by sec-mals determines the relative proportions of large (film-forming) to small (receptor-active) peptide fractions. suppliers should provide mw profile for formulation-specific selection.
Last Verified: 2026-03-22
Primary Sources: Cosing database,hydrolyzed milt extract protein hydrolysate bioactive peptide review