Common Name(s): Hexadecenoic acid,palmitoleic acid,c16:1 fatty acid,omega-7 fatty acid
CAS Number: 373-49-9
DESCRIPTION
What It Does: Softens skin and supports the natural skin barrier with a fatty acid naturally found in sebum.
Why It's Used: Palmitoleic acid (c16:1 omega-7) is a major component of human sebum and skin lipids; topical application replenishes skin surface lipids and supports barrier integrity.
How It Works: Palmitoleic acid (c16:1 omega-7) is present in sebum (~1-2%) and in macadamia, sea buckthorn, and human fat; integrates into skin surface lipid film; mild antimicrobial activity against staphylococcus aureus; supports skin barrier function.
Typically Found In: Sebum-mimetic formulas,barrier repair products,anti-aging skin care,acne-prone skin care
TECHNICAL DETAILS
Primary Category: Functional ingredient – emollient
Secondary Functions: Skin conditioning,antimicrobial,barrier support
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.1%–5%
SOURCING & ETHICS
Vegan Status: Conditional - supplier confirmation required
Halal Status: Unverified - supplier confirmation required
Source Notes: Derived from macadamia, sea buckthorn, or human adipose-derived sources; natural origin. [audit 2026-07-29 rev2: the record's own source_notes does not assert a non-animal origin, or instructs the reader to verify with the supplier; "yes" asserts knowledge the record does not hold. determination requires shariah-panel sign-off.]
SKIN COMPATIBILITY
Irritancy Rating: 1/5 – very low
Comedogenicity Rating: 1/5 – low
Sensitivity Concerns: Generally well tolerated; naturally present in skin.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Excellent safety profile. ewg score: 1.
Works Well With: Squalane,macadamia ternifolia seed oil,ceramides,other fatty acids
Avoid Combining With: Prone to oxidation; formulate with antioxidants
SCIENTIFIC NOTE
Palmitoleic acid (c16:1 omega-7) is the dominant mufa in human sebum; declines with age (sebum becomes more saturated with aging); macadamia nut oil is the richest plant source (~16-22%); used in sebum-mimetic and barrier repair formulations.
Last Verified: 2026-03-28
Primary Sources: Cosing database,inci dictionary