Common Name(s): Heptapeptide-20,heptapeptide-20,seven-residue signal peptide,anti-aging bioactive
CAS Number: N/a
DESCRIPTION
What It Does: Stimulates fibroblast collagen synthesis and inhibits mmp-1 degradation — providing clinically measurable wrinkle reduction and skin firmness at 1–5000 ppm.
Why It's Used: Hex/heptapeptide sequences provide the optimal length-activity balance — long enough for full receptor docking geometry while short enough for sc penetration without lipid anchoring.
How It Works: Peptide receptor binding → map kinase or smad signalling cascade → col1a1/col3a1 upregulation + mmp-1/mmp-3 inhibition. spps (solid-phase peptide synthesis) provides >98% sequence purity for reproducible pharmacological response.
Typically Found In: Anti-aging serums,collagen products
TECHNICAL DETAILS
Primary Category: Active ingredient – peptide
Secondary Functions: Collagen synthesis,anti-aging
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 1–5000 ppm
SOURCING & ETHICS
Vegan Status: Yes
Halal Status: Yes
Source Notes: Synthetically produced via solid-phase peptide synthesis (spps).
SKIN COMPATIBILITY
Irritancy Rating: 1/5 – very low
Comedogenicity Rating: 0/5 – non-comedogenic
Sensitivity Concerns: Non-irritating at recommended concentrations.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Excellent safety profile. ewg score: 1.
Works Well With: Retinoids,niacinamide,vitamin c,hyaluronic acid
Avoid Combining With: Strong acids below ph 3.5; oxidising agents
SCIENTIFIC NOTE
Hexapeptide/heptapeptide numbering follows inci registry sequence assignment — each number designates a distinct amino acid sequence targeting different receptor subtypes for complementary anti-aging mechanisms.
Last Verified: 2026-03-22
Primary Sources: Cosing database,heptapeptide-20 signal peptide anti-aging review