Common Name(s): Guanosine,guanosine,purine nucleoside,cellular energy dna repair anti-aging
CAS Number: N/a
DESCRIPTION
What It Does: Supports guanosine triphosphate (gtp) biosynthesis for cellular energy metabolism and g-protein signalling, provides guanosine as a dna repair substrate for uv-damaged cells, and contributes to cgmp second messenger pathways regulating keratinocyte differentiation.
Why It's Used: Gtp is as fundamental to cellular energy as atp — guanosine supplementation supports the purine nucleotide pool in uv-stressed and ageing skin where nucleotide salvage pathway efficiency declines, maintaining the energy substrates required for dna repair and cell renewal.
How It Works: Guanosine (nucleoside salvage): guanosine + guanosine kinase → gmp → gdp → gtp. gtp functions: g-protein coupled receptor signalling (gpcr activation required for egf, fgf signal transduction); ribosomal translation; tubulin polymerisation for cell division; substrate for cgmp second messenger (no-stimulated guanylate cyclase).
Typically Found In: Anti-aging,cellular energy,dna repair
TECHNICAL DETAILS
Primary Category: Active ingredient – antioxidant
Secondary Functions: Free radical scavenging,anti-aging
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.01%–1%
SOURCING & ETHICS
Vegan Status: Yes
Halal Status: Yes
Source Notes: Plant-derived extract or synthetic.
SKIN COMPATIBILITY
Irritancy Rating: 1/5 – very low
Comedogenicity Rating: 0/5 – non-comedogenic
Sensitivity Concerns: Non-irritating; well-tolerated.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Excellent safety profile. ewg score: 1.
Works Well With: Vitamin c,vitamin e,ferulic acid,spf,other antioxidants
Avoid Combining With: No significant incompatibilities
SCIENTIFIC NOTE
Purine nucleosides are gras food components (widely present in meat, mushrooms, fish) with extensive safety documentation — the food-level safety profile directly supporting cosmetic use at standard concentrations.
Last Verified: 2026-03-22
Primary Sources: Cosing database,guanosine purine nucleoside cellular energy anti-aging review