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Glycyrrhetinic Acid

Description

Glycyrrhetinic Acid is a potent bioactive compound derived from licorice root (Glycyrrhiza glabra). This triterpenoid molecule is renowned for its anti-inflammatory, antioxidant, and skin-soothing properties, making it a valuable ingredient in dermatological formulations and skincare products.

The compound works by inhibiting 11β-hydroxysteroid dehydrogenase, an enzyme responsible for converting cortisol to its inactive form. This mechanism enhances the skin's natural anti-inflammatory response, potentially reducing redness, irritation, and mild swelling. Glycyrrhetinic Acid also demonstrates antimicrobial activities, particularly against Propionibacterium acnes, a bacterium associated with acne development.

In skincare applications, Glycyrrhetinic Acid is often used to address various skin concerns, including eczema, psoriasis, and hyperpigmentation. Its ability to modulate melanin production makes it effective in treating melasma and other pigmentary disorders. The ingredient's antioxidant properties help protect the skin from free radical damage, potentially slowing the signs of aging.

Typical concentrations in skincare products range from 0.5% to 2%, depending on the specific formulation and intended use. While generally well-tolerated, prolonged use of high concentrations may lead to adverse effects in some individuals.