Common Name(s): Glutamoyl aminoguanidine,glu-aminoguanidine,anti-glycation dipeptide analog
DESCRIPTION
What It Does: Protects skin proteins from sugar-induced damage (glycation), helping maintain skin firmness and youthfulness.
Why It's Used: Glycation of skin proteins (collagen, elastin) by reducing sugars is a major contributor to skin aging; glutamoyl aminoguanidine traps reactive carbonyl intermediates preventing advanced glycation end-product (age) formation.
How It Works: Aminoguanidine provides a nucleophilic guanidine group that traps reactive dicarbonyl species (methylglyoxal, glyoxal) formed during glycation; glutamoyl modification improves skin compatibility and delivery; prevents age cross-linking of collagen.
Typically Found In: Anti-aging serums,anti-glycation products,collagen protection formulas,premium anti-aging
TECHNICAL DETAILS
Primary Category: Active ingredient – anti-aging
Secondary Functions: Antioxidant,protein protection,anti-glycation
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.1%–2%
SOURCING & ETHICS
Vegan Status: Yes
Halal Status: Yes
Source Notes: Synthetic dipeptide analog; aminoguanidine semi-synthetic.
SKIN COMPATIBILITY
Irritancy Rating: 1/5 – very low
Comedogenicity Rating: 0/5 – non-comedogenic
Sensitivity Concerns: Generally well tolerated.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Good safety profile. ewg score: 1.
Works Well With: Carnosine,vitamin b6,antioxidants,peptides,niacinamide
Avoid Combining With: No significant incompatibilities
SCIENTIFIC NOTE
Advanced glycation end-products (ages) accumulate in aging skin collagen, reducing flexibility and causing yellowing; aminoguanidine-type compounds are potent carbonyl-trapping anti-glycation agents; glutamoyl modification improves topical delivery versus free aminoguanidine.
Last Verified: 2026-03-28
Primary Sources: Cosing database,inci dictionary