Common Name(s): Galloyl sh-nonapeptide-3,galloyl sh-nonapeptide-3,phenolic-conjugated or metal-chelating peptide,dual anti-aging active
CAS Number: N/a
DESCRIPTION
What It Does: Provides combined peptide sequence receptor-mediated collagen synthesis with phenolic antioxidant protection or metal cofactor enzyme activation from one molecule.
Why It's Used: Phenolic-peptide conjugation provides dual mechanism: the peptide sequence targets the receptor while the phenolic group independently scavenges radicals or chelates metal cofactors.
How It Works: Peptide receptor binding → kinase signalling → col1a1 upregulation. feruloyl/galloyl phenolic: catechol radical scavenging from h-atom donation; iron/copper coordination providing cofactor delivery for antioxidant enzymes.
Typically Found In: Premium anti-aging,collagen products
TECHNICAL DETAILS
Primary Category: Active ingredient – peptide
Secondary Functions: Collagen synthesis,anti-aging
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 1–5000 ppm
SOURCING & ETHICS
Vegan Status: Yes
Halal Status: Yes
Source Notes: Synthetically produced via solid-phase peptide synthesis (spps).
SKIN COMPATIBILITY
Irritancy Rating: 1/5 – very low
Comedogenicity Rating: 0/5 – non-comedogenic
Sensitivity Concerns: Non-irritating at recommended concentrations.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Excellent safety profile. ewg score: 1.
Works Well With: Retinoids,niacinamide,vitamin c,hyaluronic acid
Avoid Combining With: Strong acids below ph 3.5; oxidising agents
SCIENTIFIC NOTE
Conjugate stability: phenolic-peptide amide bonds are more hydrolysis-resistant than ester bonds — the amide-linked conjugates maintain dual activity throughout product shelf life.
Last Verified: 2026-03-22
Primary Sources: Cosing database,galloyl sh-nonapeptide-3 phenolic-peptide anti-aging review