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ENDONUCLEASE V

Description

Endonuclease V is a DNA repair enzyme that plays a crucial role in maintaining genomic integrity. Originally discovered in bacteria, this enzyme has garnered significant attention in the field of dermatology and skincare for its potential applications in protecting and repairing skin cells from UV-induced damage.

Endonuclease V specifically recognizes and cleaves DNA at sites containing deaminated bases, particularly inosine, which can result from UV radiation exposure. This targeted action helps prevent mutations and maintains cellular health. In skincare formulations, endonuclease V is typically derived from bacterial sources or produced through recombinant DNA technology.

When incorporated into topical products, endonuclease V can penetrate the stratum corneum and reach viable skin cells. It works synergistically with the skin's natural repair mechanisms to enhance DNA repair processes. Studies have shown that endonuclease V can reduce the formation of cyclobutane pyrimidine dimers, a common type of UV-induced DNA damage.

Skincare products containing endonuclease V are often marketed for their photoprotective and anti-aging properties. These formulations may be particularly beneficial for individuals with sun-damaged skin or those at high risk of skin cancer.