Common Name(s): Dithiodiglycolic acid,dithiodiglycolic acid,cosmetic functional ingredient,established active

CAS Number: N/a

DESCRIPTION

What It Does: Provides polyol humectant moisture retention and co-solvent activity for active ingredient dissolution.

Why It's Used: Dithiodiglycolic acid is selected as the smallest alpha-hydroxy acid for sc penetration — glycolic acid's c2 chain provides the highest water solubility and corneodesmosome desmolysis rate among ahas, delivering the most potent chemical exfoliation per mol with the lowest formulation ph requirement.

How It Works: Hydroxyl groups h-bond water (5-7 per oh) for hygroscopic retention; alkyl chain controls lipophilicity from pure humectant to emollient.

Typically Found In: Cosmetic formulations

TECHNICAL DETAILS

Primary Category: Active ingredient – cosmetic active

Secondary Functions: Skin conditioning

Application Areas:

Typical Concentration Range: 0.1%–10%

SOURCING & ETHICS

Vegan Status: Conditional - supplier confirmation required

Halal Status: Unverified - supplier confirmation required

Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier. [audit 2026-07-29 rev2: the record's own source_notes does not assert a non-animal origin, or instructs the reader to verify with the supplier; "yes" asserts knowledge the record does not hold. determination requires shariah-panel sign-off.]

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Well-tolerated by most skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Good safety profile at recommended concentrations. ewg score: 1–2.

Works Well With: Standard skincare actives

Avoid Combining With: No known significant incompatibilities

SCIENTIFIC NOTE

Safety documented in cosing at standard formulation concentrations.

Last Verified: 2026-03-22

Primary Sources: Cosing database,dithiodiglycolic acid technical review