Common Name(s): Disodium phosphocreatine,disodium phosphocreatine,nucleotide salt,cellular energy signalling active

CAS Number: N/a

DESCRIPTION

What It Does: Provides nucleotide energy substrate for cellular atp production, activates p2 purinergic receptors on skin cells for renewal signalling, or supplies phosphate groups for phosphorylation-dependent enzymatic reactions.

Why It's Used: Nucleotide supplementation supports the energy-demanding processes of skin renewal — keratinocyte turnover and collagen synthesis require substantial atp investment, and nucleotide precursor availability can limit these processes in aged skin.

How It Works: Disodium nucleotide → purinergic receptor activation (p2y, p2x) → signalling cascades for cell renewal; or → nucleotide salvage pathway → atp production supporting energy-intensive skin cell processes. phosphocreatine → creatine kinase → immediate atp regeneration from adp.

Typically Found In: Anti-aging,cellular energy,skin renewal

TECHNICAL DETAILS

Primary Category: Active ingredient – antioxidant

Secondary Functions: Free radical scavenging,anti-aging

Application Areas:

Typical Concentration Range: 0.001%–0.5%

SOURCING & ETHICS

Vegan Status: Yes

Halal Status: Yes

Source Notes: Plant-derived extract or synthetic.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; well-tolerated.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Vitamin c,vitamin e,ferulic acid,spf,other antioxidants

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Nucleotide cosmetic applications mirror the established nucleotide supplementation in wound healing medicine — the same energy and signalling mechanisms support both wound repair and cosmetic skin renewal.

Last Verified: 2026-03-22

Primary Sources: Cosing database,disodium phosphocreatine nucleotide energy signalling review