Common Name(s): Disodium nadh,nadh sodium salt,coenzyme 1,reduced nad

DESCRIPTION

What It Does: Boosts skin cell energy and fights signs of aging at a cellular level.

Why It's Used: Nadh (the reduced form of nad+) is the primary cellular electron carrier and energy currency; topical application may support cellular bioenergetics and mitochondrial function in skin cells.

How It Works: Nadh is the reduced coenzyme form of nad+; in cells, nadh donates electrons in the electron transport chain to generate atp; topically, it provides direct antioxidant electron donation and may support cellular nad+ cycling, which declines with age.

Typically Found In: Anti-aging serums,energy-boosting skin care,mitochondrial skin care,premium formulas

TECHNICAL DETAILS

Primary Category: Active ingredient – anti-aging

Secondary Functions: Antioxidant,cellular energy support

Application Areas:

Typical Concentration Range: 0.01%–1%

SOURCING & ETHICS

Vegan Status: Yes

Halal Status: Yes

Source Notes: Synthetic or yeast-fermentation derived nadh; sodium salt form for stability.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Generally well tolerated at low concentrations.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Good safety profile. ewg score: 1.

Works Well With: Niacinamide (nad+ precursor),coq10,antioxidants,peptides

Avoid Combining With: No significant incompatibilities; sensitive to oxidation — requires careful formulation

SCIENTIFIC NOTE

Nadh (reduced nad) is the most potent endogenous antioxidant in terms of electron-donating capacity; cellular nadh/nad+ ratios decline with age contributing to mitochondrial dysfunction; topical nadh has been researched for skin energy restoration and anti-aging applications.

Last Verified: 2026-03-28

Primary Sources: Cosing database,inci dictionary