Common Name(s): Dipeptide-21,dipeptide-21,two-residue bioactive,minimal anti-aging active

CAS Number: N/a

DESCRIPTION

What It Does: Provides targeted anti-aging receptor activation for collagen synthesis or mmp inhibition — the two-residue sequence providing excellent formulation stability and sc penetration from the low mw.

Why It's Used: Dipeptides provide the simplest effective peptide anti-aging agents — two-residue sequences at the minimum viable pharmacophore provide maximum stability and penetration at minimum molecular weight.

How It Works: Dipeptide receptor binding: the two-residue sequence maintains the minimum pharmacophore for receptor recognition while providing optimal stability (resistant to most tissue dipeptidases due to non-natural amino acid or blocking groups). low mw (<300 da) enables sc penetration without lipid anchoring.

Typically Found In: Anti-aging serums,targeted actives

TECHNICAL DETAILS

Primary Category: Active ingredient – peptide

Secondary Functions: Collagen synthesis,anti-aging

Application Areas:

Typical Concentration Range: 1–5000 ppm

SOURCING & ETHICS

Vegan Status: Yes

Halal Status: Yes

Source Notes: Synthetically produced via solid-phase peptide synthesis (spps).

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating at recommended concentrations.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Retinoids,niacinamide,vitamin c,hyaluronic acid

Avoid Combining With: Strong acids below ph 3.5; oxidising agents

SCIENTIFIC NOTE

Dipeptide stability advantage: two-residue sequences are resistant to aminopeptidase if n-terminally blocked (acetyl, formyl) or contain d-amino acids — the specific modification determines in-skin half-life.

Last Verified: 2026-03-22

Primary Sources: Cosing database,dipeptide-21 anti-aging bioactive review