Common Name(s): Diosmetin,diosmetin,citrus flavone,anti-inflammatory antioxidant vascular protective
CAS Number: N/a
DESCRIPTION
What It Does: Provides vascular wall strengthening through endothelial collagen iv synthesis stimulation, dual cox/lox anti-inflammatory activity, and antioxidant radical scavenging for anti-redness and periorbital circle reduction applications.
Why It's Used: Diosmetin is the most bioavailable form of the diosmin/hesperidin vascular-protective family — the aglycone directly activates the vascular targets without requiring glycosidase activation, providing faster onset of capillary-strengthening activity.
How It Works: Diosmetin (3',4'-dihydroxyflavone 7-methyl ether): catechol b-ring inhibits 5-lox (ic50 ~5 μm) and cox-1/2 (ic50 ~10 μm) through active site competition; inhibits hyaluronidase protecting capillary basement membrane ha; activates hif-1α for vegf-dependent capillary wall remodelling.
Typically Found In: Anti-redness,periorbital care,vascular skin care
TECHNICAL DETAILS
Primary Category: Active ingredient – antioxidant
Secondary Functions: Free radical scavenging,anti-aging
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.01%–1%
SOURCING & ETHICS
Vegan Status: Yes
Halal Status: Yes
Source Notes: Plant-derived extract or synthetic.
SKIN COMPATIBILITY
Irritancy Rating: 1/5 – very low
Comedogenicity Rating: 0/5 – non-comedogenic
Sensitivity Concerns: Non-irritating; well-tolerated.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Excellent safety profile. ewg score: 1.
Works Well With: Vitamin c,vitamin e,ferulic acid,spf,other antioxidants
Avoid Combining With: No significant incompatibilities
SCIENTIFIC NOTE
Diosmetin peripheral vascular application: the same capillary-strengthening mechanism is the basis of diosmin pharmaceutical use for chronic venous insufficiency — cosmetic concentrations provide the same mechanism for facial capillary reinforcement and periorbital circle reduction.
Last Verified: 2026-03-22
Primary Sources: Cosing database,diosmetin citrus flavone vascular anti-inflammatory review