Common Name(s): Dihydromyricetin,dihydromyricetin (ampelopsin),ampelopsis flavanone,anti-glycation antioxidant

CAS Number: N/a

DESCRIPTION

What It Does: Provides exceptional antioxidant radical scavenging from the dihydroflavonol catechol groups (dpph ic50 ~2 μm — among the highest of any flavonoid), anti-glycation protection from age intermediate trapping, and anti-inflammatory ampk activation.

Why It's Used: Dihydromyricetin's ortho-3',4',5'-trihydroxy arrangement provides three sequential h-atom donations — the trihydroxy b-ring catechol/pyrogallol providing exceptional radical scavenging with three antioxidant equivalents per molecule versus one for most polyphenols.

How It Works: Dihydromyricetin catechol (3',4'-oh) + pyrogallol (3',4',5'-oh) b-ring: three sequential h-atom donations to peroxyl radicals providing three antioxidant equivalents. anti-glycation: trihydroxy b-ring forms schiff base adducts with reactive carbonyl species (methylglyoxal) preventing age formation on collagen lysines. ampk activation → mtor inhibition → autophagy → cellular quality control.

Typically Found In: Premium antioxidant,anti-aging,anti-glycation

TECHNICAL DETAILS

Primary Category: Active ingredient – antioxidant

Secondary Functions: Free radical scavenging,anti-aging

Application Areas:

Typical Concentration Range: 0.01%–1%

SOURCING & ETHICS

Vegan Status: Yes

Halal Status: Yes

Source Notes: Plant-derived extract or synthetic.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; well-tolerated.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Vitamin c,vitamin e,ferulic acid,spf,other antioxidants

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Dihydromyricetin as a traditional tea ingredient: the plant ampelopsis grossedentata (chinese vine tea, mao jian tea) is consumed traditionally — extensive food safety documentation from traditional use supporting cosmetic application at equivalent concentrations.

Last Verified: 2026-03-22

Primary Sources: Cosing database,dihydromyricetin ampelopsin antioxidant anti-glycation review