Common Name(s): Deoxyribonuclease,deoxyribonuclease (dnase),dna hydrolase enzyme,anti-biofilm wound healing active
CAS Number: N/a
DESCRIPTION
What It Does: Degrades extracellular dna in bacterial biofilms disrupting biofilm matrix structure, clears necrotic dna debris from wound beds enabling fibroblast migration, and reduces tlr9-mediated inflammatory signalling from extracellular dna.
Why It's Used: Extracellular dna (edna) is the primary structural component of bacterial biofilms — without edna cross-linking, the biofilm collapses, making dnase the most targeted anti-biofilm strategy available.
How It Works: Dnase i hydrolyses phosphodiester bonds in dna producing 5'-phosphate fragments. biofilm edna: s. aureus and p. aeruginosa biofilms contain 5-25% edna by mass — dnase treatment (0.1-1 μg/ml) reduces biofilm biomass by 50-90%. wound debridement: edna from necrotic cells inhibits fibroblast migration; dnase clears this scaffold restoring the wound healing environment.
Typically Found In: Wound care,anti-biofilm,anti-acne
TECHNICAL DETAILS
Primary Category: Active ingredient – cosmetic active
Secondary Functions: Skin conditioning
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.001%–0.1%
SOURCING & ETHICS
Vegan Status: Conditional - supplier confirmation required
Halal Status: Unverified - supplier confirmation required
Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier. [audit 2026-07-29 rev2: the record's own source_notes does not assert a non-animal origin, or instructs the reader to verify with the supplier; "yes" asserts knowledge the record does not hold. determination requires shariah-panel sign-off.]
SKIN COMPATIBILITY
Irritancy Rating: 1/5 – very low
Comedogenicity Rating: 0/5 – non-comedogenic
Sensitivity Concerns: Well-tolerated by most skin types.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Good safety profile at recommended concentrations. ewg score: 1–2.
Works Well With: Standard skincare actives
Avoid Combining With: No known significant incompatibilities
SCIENTIFIC NOTE
Dnase formulation stability: dnase i requires ca²⁺ and mg²⁺ cofactors (optimal 5 mm each) for catalytic activity and ph 5-7 for stability. edta-containing formulations inactivate dnase through metal chelation — avoid combining with chelating preservatives.
Last Verified: 2026-03-22
Primary Sources: Cosing database,deoxyribonuclease anti-biofilm wound healing enzyme review