Common Name(s): Decapeptide-29,decapeptide-29,ten-residue anti-aging signal peptide,receptor-targeted collagen stimulator
CAS Number: N/a
DESCRIPTION
What It Does: Stimulates fibroblast collagen i, iii, iv synthesis and inhibits mmp-1 collagen degradation — providing measurable anti-aging wrinkle reduction and skin firmness at ppm concentrations.
Why It's Used: Decapeptide sequences provide the minimum length for full receptor binding geometry while maintaining sufficient flexibility for induced-fit docking at the target receptor active site.
How It Works: Decapeptide receptor binding → map kinase or smad cascade → col1a1/col3a1 upregulation + mmp-1 downregulation. spps synthesis provides >98% sequence purity for reproducible pharmacology.
Typically Found In: Anti-aging serums,collagen products
TECHNICAL DETAILS
Primary Category: Active ingredient – peptide
Secondary Functions: Collagen synthesis,anti-aging
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 1–5000 ppm
SOURCING & ETHICS
Vegan Status: Yes
Halal Status: Yes
Source Notes: Synthetically produced via solid-phase peptide synthesis (spps).
SKIN COMPATIBILITY
Irritancy Rating: 1/5 – very low
Comedogenicity Rating: 0/5 – non-comedogenic
Sensitivity Concerns: Non-irritating at recommended concentrations.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Excellent safety profile. ewg score: 1.
Works Well With: Retinoids,niacinamide,vitamin c,hyaluronic acid
Avoid Combining With: Strong acids below ph 3.5; oxidising agents
SCIENTIFIC NOTE
Decapeptide numbering follows inci registry assignment — each numbered decapeptide has a distinct amino acid sequence targeting different receptor subtypes for complementary anti-aging mechanisms.
Last Verified: 2026-03-22
Primary Sources: Cosing database,decapeptide-29 anti-aging signal peptide review