Common Name(s): Cocoyl hexapeptide-16,cocoyl hexapeptide-16,signal peptide or amino acid active,anti-aging bioactive
CAS Number: N/a
DESCRIPTION
What It Does: Provides receptor-mediated collagen synthesis stimulation, enzyme cofactor activity, or amino acid metabolic support for skin renewal at recommended cosmetic concentrations.
Why It's Used: Precision amino acid and peptide actives provide mechanism-based anti-aging efficacy — defined molecular structure enabling quantifiable receptor pharmacology and reproducible clinical outcomes.
How It Works: Amino acid/peptide interaction with skin: receptor binding → kinase cascade → gene expression change; or enzyme cofactor → metabolic pathway support; or osmolyte → cellular stress protection.
Typically Found In: Anti-aging serums,collagen products
TECHNICAL DETAILS
Primary Category: Active ingredient – peptide
Secondary Functions: Collagen synthesis,anti-aging
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 1–5000 ppm
SOURCING & ETHICS
Vegan Status: Conditional - feedstock declaration required
Halal Status: Unverified - feedstock declaration required (plant, animal and petrochemical routes all exist)
Source Notes: Synthetically produced via solid-phase peptide synthesis (spps). [audit 2026-07-29 rev2: origin-dependent: the same inci exists in plant, animal and petrochemical versions and the name does not discriminate. determination requires shariah-panel sign-off.]
SKIN COMPATIBILITY
Irritancy Rating: 1/5 – very low
Comedogenicity Rating: 0/5 – non-comedogenic
Sensitivity Concerns: Non-irritating at recommended concentrations.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Excellent safety profile. ewg score: 1.
Works Well With: Retinoids,niacinamide,vitamin c,hyaluronic acid
Avoid Combining With: Strong acids below ph 3.5; oxidising agents
SCIENTIFIC NOTE
Peptide formulation consideration: maintain ph 5-7 for optimal stability; avoid oxidising conditions that modify thiol and tryptophan residues; consider encapsulation for hydrophobic sequences.
Last Verified: 2026-03-22
Primary Sources: Cosing database,cocoyl hexapeptide-16 peptide amino acid anti-aging review