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CILOSTAMIDE

Description

Cilostamide is a potent and selective phosphodiesterase-3 (PDE3) inhibitor with promising applications in dermatology and skincare. This synthetic compound works by increasing intracellular levels of cyclic adenosine monophosphate (cAMP), which plays a crucial role in various cellular processes, including melanogenesis and keratinocyte differentiation.

In skincare formulations, cilostamide has shown potential for addressing hyperpigmentation and improving overall skin tone. It inhibits melanin production by suppressing the activity of tyrosinase, a key enzyme in melanogenesis. This action makes cilostamide an effective ingredient for treating conditions such as melasma, age spots, and post-inflammatory hyperpigmentation.

Additionally, cilostamide exhibits anti-inflammatory properties, which can help reduce skin redness and irritation. Its ability to modulate keratinocyte differentiation may contribute to improved skin barrier function and hydration. Research suggests that cilostamide may also have antioxidant effects, potentially protecting the skin from environmental stressors and free radical damage.

When formulating with cilostamide, it is typically used in concentrations ranging from 0.1% to 1%. It is compatible with various skincare vehicles, including creams, serums, and gels.