Common Name(s): Vitamin d3,colecalciferol
CAS Number: 67-97-0
DESCRIPTION
What It Does: Supports skin barrier protein synthesis, regulates keratinocyte differentiation, reduces inflammation.
Why It's Used: Therapeutic and functional skincare for cell differentiation regulation, barrier protein synthesis, and anti-inflammatory properties.
How It Works: Binds vitamin d receptor (vdr) in keratinocytes and immune cells, regulating differentiation, barrier protein synthesis (filaggrin, loricrin), and inflammatory cytokine modulation.
Typically Found In: Therapeutic skin products,psoriasis treatments,eczema care,barrier repair
TECHNICAL DETAILS
Primary Category: Active ingredient โ vitamin d3
Secondary Functions: Keratinocyte differentiation,anti-inflammatory,barrier protein synthesis
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.001%โ0.1%
SOURCING & ETHICS
Vegan Status: Conditional - feedstock declaration required
Halal Status: Unverified - feedstock declaration required (plant, animal and petrochemical routes all exist)
Source Notes: Traditionally from lanolin. vegan d3 from cladonia lichen. verify source for vegan/halal certification. [audit 2026-07-29 rev2: origin-dependent: the same inci exists in plant, animal and petrochemical versions and the name does not discriminate. determination requires shariah-panel sign-off.]
SKIN COMPATIBILITY
Irritancy Rating: 1/5 โ very low
Comedogenicity Rating: 0/5 โ non-comedogenic
Sensitivity Concerns: Non-irritating at cosmetic concentrations.
Safe for Sensitive Skin: Yes at cosmetic concentrations
SAFETY & COMPATIBILITY
Safety Profile: Safe at cosmetic concentrations. ewg score: 1.
Works Well With: Ceramides,retinoids,anti-inflammatory actives
Avoid Combining With: No significant incompatibilities
SCIENTIFIC NOTE
Vdr activation upregulates filaggrin (flg) and other barrier proteins crucial for skin hydration. filaggrin deficiency (common in atopic dermatitis) is a major barrier dysfunction cause. topical d3 may partially restore filaggrin expression.
Last Verified: 2026-03-12
Primary Sources: Cosing database,bikle vitamin d skin review,cir safety assessment