Common Name(s): Capsaicin,chilli trpv1 agonist,anti-itch anti-pain active

CAS Number: N/a

DESCRIPTION

What It Does: Activates then desensitises trpv1 on sensory neurons, depleting substance p to reduce neurogenic inflammation and itch signalling, and provides the warming sensation used in anti-cellulite and circulation-stimulating formulations.

Why It's Used: The only cosmetic active that works through controlled receptor desensitisation — the initial trpv1 activation and substance p depletion provides long-duration anti-itch benefit that persists well beyond the ingredient's presence, through the receptor down-regulation mechanism.

How It Works: Capsaicin binds trpv1 channel's capsaicin binding domain (s2-s4 transmembrane segments) → channel opening → ca²⁺ influx → substance p and cgrp release (initial burning). prolonged activation depletes substance p stores and internalises trpv1 receptors → desensitisation phase: reduced itch, reduced neurogenic vasodilation, reduced inflammatory peptide release.

Typically Found In: Anti-itch,warming circulation,anti-cellulite

TECHNICAL DETAILS

Primary Category: Active ingredient – cosmetic active

Secondary Functions: Skin conditioning

Application Areas:

Typical Concentration Range: 0.025%–0.1%

SOURCING & ETHICS

Vegan Status: Conditional - supplier confirmation required

Halal Status: Unverified - supplier confirmation required

Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier. [audit 2026-07-29 rev2: the record's own source_notes does not assert a non-animal origin, or instructs the reader to verify with the supplier; "yes" asserts knowledge the record does not hold. determination requires shariah-panel sign-off.]

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Well-tolerated by most skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Good safety profile at recommended concentrations. ewg score: 1–2.

Works Well With: Standard skincare actives

Avoid Combining With: No known significant incompatibilities

SCIENTIFIC NOTE

Capsaicin's therapeutic concentration window is narrow — below 0.025% insufficient desensitisation; above 0.1% prolonged irritation without clinical benefit. the trpv1 desensitisation efficacy requires repeated application over several days to fully deplete substance p stores.

Last Verified: 2026-03-12

Primary Sources: Cosing database,capsaicin trpv1 desensitisation anti-itch review