Common Name(s): N-capryloyl glycine,dermosoft gmcy
CAS Number: 14246-53-8
DESCRIPTION
What It Does: Provides antimicrobial and sebum-regulating activity from naturally-derived caprylic acid-glycine conjugate.
Why It's Used: Natural multifunctional antimicrobial โ capryloyl glycine's anti-seborrheic and antimicrobial dual action provides comprehensive oily skin and anti-dandruff benefits from a single naturally-sourced ingredient.
How It Works: Acyl glycine conjugate provides antimicrobial via fatty acid membrane disruption mechanism. inhibits lipase enzyme reducing sebum fatty acid liberation (sebum regulation). mild surfactant from carboxylate head group. anti-dandruff via malassezia inhibition.
Typically Found In: Anti-seborrheic products,natural antimicrobials,anti-dandruff
TECHNICAL DETAILS
Primary Category: Functional ingredient โ acyl amino acid surfactant/preservative
Secondary Functions: Skin conditioning
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.5%โ2%
SOURCING & ETHICS
Vegan Status: Conditional - feedstock declaration required
Halal Status: Unverified - feedstock declaration required (plant, animal and petrochemical routes all exist)
Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier. [audit 2026-07-29 rev2: origin-dependent: the same inci exists in plant, animal and petrochemical versions and the name does not discriminate. determination requires shariah-panel sign-off.]
SKIN COMPATIBILITY
Irritancy Rating: 1/5 โ very low
Comedogenicity Rating: 0/5 โ non-comedogenic
Sensitivity Concerns: Well-tolerated by most skin types.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Good safety profile at recommended concentrations. ewg score: 1โ2.
Works Well With: Standard skincare actives
Avoid Combining With: No known significant incompatibilities
SCIENTIFIC NOTE
Capryloyl glycine's sebum regulation via lipase inhibition mirrors the same mechanism as triethyl citrate and ethylhexylglycerin โ convergent mechanism discovery across structurally diverse ingredient classes. the parallel lipase inhibition by ester-based (triethyl citrate), ether-based (ethylhexylglycerin), and amide-based (capryloyl glycine) compounds validates lipase inhibition as a universally accessible target for sebum control through multiple chemical approaches.
Last Verified: 2026-03-12
Primary Sources: Cosing database,schรผlke dermosoft gmcy technical data