Common Name(s): Butyl hydroxycyclohexane carboxylate,butyl hydroxycyclohexane carboxylate,cooling agent,non-menthol trpm8 activator
CAS Number: N/a
DESCRIPTION
What It Does: Provides trpm8-mediated cooling sensation without menthol's peppermint fragrance โ the hydroxycyclohexane carboxylate geometry activating cold receptor trpm8 for the cooling perception used in deodorants, after-sun, and cooling skin products.
Why It's Used: Cyclohexane carboxylate cooling agents provide cooling function separated from menthol's overpowering peppermint scent โ enabling cooling product positioning in fragrance-sensitive applications and combination with non-peppermint fragrances.
How It Works: Hydroxycyclohexane carboxylate binds trpm8 at the hydrophobic pocket formed by s1-s4 transmembrane domains โ the hydroxyl group h-bonds with tyr745 while the cyclohexane occupies the lipophilic binding groove. the ester provides improved hydrolytic stability versus menthol ether analogues.
Typically Found In: Cooling cosmetics,deodorant,after-sun
TECHNICAL DETAILS
Primary Category: Active ingredient โ cosmetic active
Secondary Functions: Skin conditioning
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.01%โ0.5%
SOURCING & ETHICS
Vegan Status: Conditional - supplier confirmation required
Halal Status: Unverified - supplier confirmation required
Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier. [audit 2026-07-29 rev2: the record's own source_notes does not assert a non-animal origin, or instructs the reader to verify with the supplier; "yes" asserts knowledge the record does not hold. determination requires shariah-panel sign-off.]
SKIN COMPATIBILITY
Irritancy Rating: 1/5 โ very low
Comedogenicity Rating: 0/5 โ non-comedogenic
Sensitivity Concerns: Well-tolerated by most skin types.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Good safety profile at recommended concentrations. ewg score: 1โ2.
Works Well With: Standard skincare actives
Avoid Combining With: No known significant incompatibilities
SCIENTIFIC NOTE
Trpm8 cooling potency varies with cyclohexyl substitution: equatorial hydroxyl provides higher receptor affinity than axial; carboxylate ester improves formulation stability. cooling potency compared to menthol: typically ec50 ~50-100 ฮผm vs menthol ec50 ~10 ฮผm.
Last Verified: 2026-03-22
Primary Sources: Cosing database,butyl hydroxycyclohexane carboxylate trpm8 cooling review