Common Name(s): Pineapple protease,stem bromelain,ananas comosus enzyme

CAS Number: 9001-00-7

DESCRIPTION

What It Does: Provides gentle enzymatic exfoliation with anti-inflammatory and anti-edema activity beyond simple keratolysis.

Why It's Used: Multi-function enzyme providing exfoliation + anti-inflammatory activity – ideal for post-procedure formulations requiring both resurfacing and calming.

How It Works: Cysteine protease digests keratin for exfoliation (similar to papain). additionally inhibits nf-kb, reduces prostaglandin e2, and breaks down fibrin (anti-edema). anti-inflammatory activity is retained at sub-exfoliating concentrations for standalone soothing use.

Typically Found In: Enzyme peels,post-procedure products,anti-inflammatory serums,brightening masks

TECHNICAL DETAILS

Primary Category: Active ingredient – enzyme

Secondary Functions: Dual exfoliation+anti-inflammatory,fibrin dissolution

Application Areas:

Typical Concentration Range: 1%–10%

SOURCING & ETHICS

Vegan Status: Conditional - supplier confirmation required

Halal Status: Unverified - supplier confirmation required

Source Notes: Plant-derived (papaya, pineapple) or fermentation-derived. [audit 2026-07-29 rev2: status downgraded on audit. determination requires shariah-panel sign-off.]

SKIN COMPATIBILITY

Irritancy Rating: 2/5 – low to moderate

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Patch test recommended; potential for enzymatic sensitization.

Safe for Sensitive Skin: Use with caution – potential sensitization

SAFETY & COMPATIBILITY

Safety Profile: Safe at cosmetic concentrations. patch test recommended. ewg score: 1–2.

Works Well With: Ahas (synergistic),hyaluronic acid,ceramides

Avoid Combining With: High concentrations on sensitive or compromised skin

SCIENTIFIC NOTE

Bromelain's fibrinolytic activity (dissolving fibrin that accumulates at wound and inflammation sites) is a unique enzyme property not shared by papain. this fibrin dissolution reduces the persistent edema that characterizes chronic post-inflammatory states, making bromelain uniquely valuable in post-procedure inflammation management.

Last Verified: 2026-03-12

Primary Sources: Cosing database,akhtar et al. bromelain anti-inflammatory review