Common Name(s): Alpha-bisabolol,levomenol,(-)-alpha-bisabolol
CAS Number: 515-69-5
DESCRIPTION
What It Does: Reduces skin inflammation, soothes irritation, promotes wound healing, and enhances penetration of co-formulated actives.
Why It's Used: Premium natural soothing active with combined anti-inflammatory, wound healing, and penetration-enhancing activity โ clinically validated across sensitive, reactive, and irritated skin types.
How It Works: Inhibits nf-kb pathway reducing pro-inflammatory cytokines il-1ฮฒ, il-6, tnf-ฮฑ. enhances stratum corneum lipid fluidity increasing penetration of co-delivered actives. antimicrobial against s. aureus and c. albicans. promotes keratinocyte migration for wound healing.
Typically Found In: Sensitive skin products,post-procedure formulations,anti-irritant formulas,wound healing
TECHNICAL DETAILS
Primary Category: Active ingredient โ soothing / anti-inflammatory
Secondary Functions: Anti-inflammatory,penetration enhancement,antimicrobial
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.1%โ1%
SOURCING & ETHICS
Vegan Status: Conditional - supplier confirmation required
Halal Status: Unverified - supplier confirmation required
Source Notes: Natural (-)-alpha-bisabolol from brazilian candeia tree is more sustainable and potent than chamomile-derived bisabolol. synthetic (ยฑ)-bisabolol is racemic with slightly lower anti-inflammatory potency. [audit 2026-07-29 rev2: status downgraded on audit. determination requires shariah-panel sign-off.]
SKIN COMPATIBILITY
Irritancy Rating: 1/5 โ very low
Comedogenicity Rating: 0/5 โ non-comedogenic
Sensitivity Concerns: Non-irritating; ideal for reactive and sensitive skin.
Safe for Sensitive Skin: Yes โ particularly recommended for sensitive skin
SAFETY & COMPATIBILITY
Safety Profile: Excellent safety profile. ewg score: 1.
Works Well With: Ceramides,panthenol,allantoin,hyaluronic acid,centella asiatica
Avoid Combining With: No significant incompatibilities
SCIENTIFIC NOTE
Bisabolol's dual function as both an anti-inflammatory and a penetration enhancer is synergistic โ by reducing the inflammatory response that increases barrier tightness while simultaneously fluidizing stratum corneum lipids, it provides enhanced delivery of co-formulated actives in the very conditions where delivery is most needed.
Last Verified: 2026-03-12
Primary Sources: Cosing database,piazza et al. bisabolol anti-inflammatory study,cir safety assessment